The effect of Guizhi decoction on inflammatory response induced by myocardial ischemia

We aim to explore the influence of Guizhi decoction(GD) on inflammatory response in myocardial ischemia models. 45 New Zealand rabbits were divided into three groups randomly: sham control group, group and + decoction treatment group. The treated with or saline for 20 days. After that, model was created by left anterior descending coronary artery ligation. Color Doppler Echocardiography computed ejection fraction (EF). Serum content MyD88 TNF-α concentration cardiac markers (CK-MB, CK, LDH cTnT) measured. ligation, ST segment elevated. However, 15 died due operation postoperative care, excluded from this study. final sample size (n=10), (n=10) Compared decreased expression TLR4, MyD88, TNF-α,CK-MB, cTnT increased (p<0.05). decoction, EF improved related factors (p <0.05). Pretreatment attenuated level proinflammatory heart function animal ischemia.